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VOL. 2, ISSUE 1 (2026)
Therapeutic potential of anti-inflammatory diets in Nipah Virus–related complications
Authors
Dipankar Paul, Debasmita Sarkar, Atifa Ismail, Khan Farhana Mahreen
Abstract
Nipah virus (NiV) is
a highly lethal, biosafety level-4 paramyxovirus causing acute respiratory
distress syndrome (ARDS) and fulminant encephalitis, with case fatality rates
up to 100%. Given the absence of globally licensed vaccines or definitive
antiviral therapies, clinical management relies on supportive care to battle
the virus's primary driver of mortality: a host-mediated, hyper-inflammatory
cytokine storm that causes systemic vasculitis and severe tissue damage. This
review explores the therapeutic potential of anti-inflammatory diets rich in
immunomodulatory bioactives as an accessible, dual-action adjunctive therapy.
Structural in silico docking
models indicate that dietary flavonoids and polyphenols, such as naringin and
luteolin, successfully bind to critical NiV entry and fusion proteins,
outperforming traditional small-molecule options like ribavirin. Concurrently,
bioactives like curcumin and 6-gingerol suppress key pro-inflammatory mediators
($PGE_2$ and $TXA_2$) and rate-limiting viral enzymes, effectively mitigating
neutrophil infiltration in pulmonary tissues and stabilizing the blood–brain
barrier against cerebral vasculitis. Ultimately, while nutritional
interventions cannot replace standard critical care or biosafety containment,
targeted anti-inflammatory diets represent a highly scalable, non-toxic
strategy to protect tissue integrity and prevent multi-organ failure, though in
vivo animal challenges remain necessary to translate these promising
dynamics into validated clinical outbreak protocols.
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Pages:60-62
How to cite this article:
Dipankar Paul, Debasmita Sarkar, Atifa Ismail, Khan Farhana Mahreen "Therapeutic potential of anti-inflammatory diets in Nipah Virus–related complications". World Journal of Current Research, Vol 2, Issue 1, 2026, Pages 60-62
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